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Modified nanodiamond can be used as the carrier of directional drug delivery

wallpapers News 2021-04-27
Modified nanodiamond can be used as the carrier of directional drug delivery
Reports from the Russian Academy of Sciences website Siberian branch, the branch of Krasnoyarsk science center and south Korean counterparts joint research team by explosion method, the nanodiamond production were modified to make it become the carrier of directional delivery and can have prolonged drug release at the same time, improve the effectiveness of treatment efficacy.
 
Nanodiamond is absorbent, and its surface can absorb a variety of substances, including drugs. Based on this characteristic, a targeted drug delivery system for lesions with long-term therapeutic effects can be developed. This system can improve the efficacy of drugs by prolonging the pharmacological effect and reducing the dose of drugs. The Russian and Korean joint scientific research team used sodium chloride to treat the nano-diamond produced by explosive method to improve its colloidal stability in aqueous solution, that is, no agglomeration and precipitation occurred. Therefore, the nano-diamond can better "capture" and slowly "release" the absorbed substances.
 
Team by methylprednisone and dexamethasone as adsorption test reagents, such drugs in the treatment of broad-spectrum, can be used to include rheumatism, skin, allergies, asthma and chronic obstructive pulmonary disease (COPD), a variety of disease treatment, the researchers first place the nanodiamond in pharmaceutical drug adsorption in aqueous solution, then observe how carrier adsorption of drug release. Tests prove that the modified nanometer diamond drug fixed ability could be improved by more than 50%, and the adsorption material also greatly enhance the combination of strength, thus ensures the longer time to release, in comparison, unmodified nanodiamond in 9 hours can release more than 80% of the adsorption of drugs, and the modified nanometer diamond at the same time release only 50%, This demonstrates the potential of modified nano-diamond as a directional drug delivery carrier. On this basis, the joint team selected corticosteroids (hormones produced by the adrenal glands) as adsorbed agents to verify the applicability of nano-diamond as a directional drug delivery carrier.

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